Legal Notice

 

External Advisory Board Member Germany

Prof. Dr. Matthias Frosch

Chairman
Institute of Hygiene and Microbiology
University of Würzburg
Josef-Schneider-Str.2
97080 Würzburg
Germany

 

 

CV  
Born: 24.2.1960 in Mainz
Marital status: married to Dr. Petra Frosch, 3 children
1979-1986 Study in medicine, University of Mainz
1986 MD thesis in Medical Microbiology (Prof. D. Bitter-Suermann), Institute of Medical Microbiology, Mainz
1986-1987 Post-Doc, Max-Planck Institut of Biology (Prof. T.F. Meyer), Tübingen
1987-1994 Group Leader, Institute of Medical Microbiology, Medical School Hannover
1992 Habilitation Medical Microbiology, Medical School Hannover
1994-1996 Hermann- and Lilly Schilling Professorship, Medical School Hannover
since 1996 Professor (C4) of Hygiene and Microbiology, University of Würzburg
   
Selected Awards
1986 Heinz-Maier-Leibnitz Award (Deutsche Forschungsgemeinschaft)
1986 Tancré Award (Medical Faculty, University of Mainz)
1993 Research Award (Deutsche Gesellschaft für Pädiatrische Infektiologie)
1995 bioMerieux Diagnostik Award (Deutsche Gesellschaft für Hygiene und Mikrobiologie)
1998 Research Award, Deutsche Gesellschaft für Hygiene und Mikrobiologie
2003 offer of a C4-professorship for Hygiene and Medical Microbiology, University of Heidelberg
   

Project Management / Advisory Board

2001-2005

Co-ordinator "Implication of meningococcal epidemiology and population biology on public health in Europe", EU Biomed

2001-2006

Co-ordinator „Genomforschung an pathogenen Bakterien" BMBF

2004-

Member of the scientific advisory board ERA-NET „Pathogenomics"
 

Functions in Societies

1999-2004

Secretary of the German Society of Hygiene and Microbiology

2004-2006

President of the German Society of Hygiene and Microbiology

2001-

Member of the scientific board of the association Berufsverband der Ärzte für Mikrobiologie und Infektionsepidemiologie
 

Editorial work

since 1999

Editorial Board "International Journal of Medical Microbiology"

since 2002

Editor "Journal of Infection"
 
Areas of Scientific Expertise
Neisseria meningitidis pathogenesis, epidemiology and population biology
Genome research of pathogenic bacteria
Host-parasite interaction in helmintic infections (Echinococcus multilocularis)
 

Selected Publications (since 1996):

  1. Hammerschmidt, S., Hilse, R., van Putten, J.P.M., Gerardy-Schahn, R., Unkmeir, A., Frosch, M. 1996. Modulation of cell surface sialic acid expression in Neisseria meningitidis via a transposable genetic element. EMBO J. 15: 192-198.
  2. Klein, N.J., Ison, C., Peakman, M., Levin, M., Hammerschmidt, S., Frosch, M. , Heyderman, R.S. 1996. The influence of capsulation and lipooligosaccharide sialylation on neutrophil adhesion molecule expression and endothelial injury by Neisseria meningitidis . J. Infect. Dis., 173: 172-179.
  3. Petering, H., Hammerschmidt, S., Frosch, M. , van Putten, J.P.M., Ison, C., Robertson, B.D. 1996. Genes associated with the meningococcal capsule gene complex are also found in Neisseria gonorrhoeae . J. Bacteriol., 178: 3342-3345.
  4. Hammerschmidt, S., Müller, A., Sillmann, H., Mühlenhoff, M., Borrow, R., Fox, A., vanPutten, J., Zollinger, W., Gerardy-Schahn, R., Frosch, M. 1996. Capsule phase variation in Neisseria meningitidis serogroup B by slipped-strand misspairing in the polysialyltransferase gene ( siaD ): correlation with bacterial invasion and the outbreak of meningococcal disease. Mol. Microbiol., 20: 1221-1233.
  5. Jura, H., Bader, A., Hartmann, M., Mascheck, H., Frosch, M. 1996. Hepatic tissue culture model for the study of host-parasite interactions in alveolar echinococcosis. Infect. Immun., 64: 3483-3490.
  6. Mühlenhoff, M., Eckhardt, M., Bethe, A., Frosch, M. , Gerardy-Schahn, R. 1996. Polysialylation of NCAM by a single enzyme. Current Biology, 6: 188-1191
  7. Mühlenhoff, M., Eckhardt, M., Bethe, A., Frosch, M. , Gerardy-Schahn, R. 1996. Autocatalytic polysialylation of polysialyltransferase-1. EMBO J., 15: 6943-6950.
  8. Vogel, U., Weinberger, A., Frank, R., Müller, A., Köhl, J., Attkinson, J., Frosch, M. 1997. Complement factor C3 deposition and serum resistance in isogenic capsule and lipooligosaccharide sialic acid mutants of serogroup B Neisseria meningitidis . Infect. Immun., 65: 4022-4029.
  9. de Vries, F.P., Cole, R., Dankert, J., Frosch, M. , van Putten J.P.M. 1998. Neisseria meningitidis producing the Opc adhesin binds epithelial cell proteoglycan receptors. Mol. Microbiol., 27: 1203-1212.
  10. Jack, D.L., Dodds, A.W., Anwar, N., Ison, C.A., Law, A., Frosch, M. , Turner, M.W., Klein, N.J. 1998. Activation of complement by mannose-binding lectin on isogenic mutants of Neisseria meningitidis serogroup B. J. Immunol., 160: 1346-53.
  11. Lüneberg, E., Zähringer, U., Knirel, Y.A., Steinmann, D., Hartmann, M., Steinmetz, I., Rohde, M., Köhl, J., Frosch, M. 1998. Phase-variable expression of lipopolysaccharide contributes to the virulence of Legionella pneumpohila . J. Exp. Med., 188: 49-60.
  12. Paul, R., Lorenzl, S., Koedel, U., Sporer, B., Vogel, U., Frosch, M. , Pfister, H.W. 1998. Matrix metalloproteinases contribute to the blood-brain barrier disruption during bacterial meningitis. Ann. Neurol., 44: 592-600.
  13. Vogel, U., Claus, H., Frosch, M. 2000. The velocity of natural serogroup switching in Neisseria meningitidis . New Engl. J. Med., 342: 219-220.
  14. El Barkani, A., Kurzai, O., Fonzi, W.A., Ramon, A, Porta, A., Frosch, M. , Mühlschlegel, F.A. 2000. Dominant active alleles of RIM101 ( PRR2 ) bypass the pH restriction on filamentation of Candida albicans . Mol. Cell. Biol. 20: 4635-4647.
  15. Brehm, K., Jensen, K., Frosch, M. 2000. mRNA trans-splicing in the human parasitic cestode Echinococcus multilocularis . J. Biol. Chem., 275: 38311-38318.
  16. Kolb-Mäurer, A., Unkmeir, A., Kämmerer, U., Hübner, C., Leimbach T., Stade, A., Kämpgen, E., Frosch, M. , Dietrich, D. 2001. Interaction of Neisseria meningitidis with human dendritic cells. Infect. Immun., 69: 6912-6922.
  17. Jack, D.L., Read, R.C., Tenner, A.J., Frosch, M. , Turner, M.W., Klein, N.J. 2001. Mannose-binding lectin regulates the inflammatory response of human professional phagocytes to Neisseria meningitidis serogroup B. J. Infect. Dis. 184: 1152-1162.  
  18. Guckenberger, M., Kurz, S., Aepinus, C., Theiss, S., Haller, S., Leimbach, T., Panzner, U., Weber, J., Paul, H., Unkmeir, A., Frosch, M. , Dietrich, G. 2002. Analysis of the heat-shock response of Neisseria meningitidis with cDNA- and oligonucleotide-based DNA microarrays. J. Bacteriol., 184: 2546-2551.
  19. Unkmeir, A., Kämmerer, U., Stade, A., Hübner, C., Haller, S., Kolb-Mäurer, A., Frosch, M. , Dietrich, G. 2002. Lipooligosaccharide and polysaccharide capsule: virulence factors of Neisseria meningitidis that determine meningococcal interaction with human dendritic cells. Infect. Immun., 70: 2454-2462.
  20. Unkmeir, A., Latsch, K., Dietrich, G., Wintermeyer, E., Schinke, B., Schwender, S., Kim, K.S., Eigenthaler, M., Frosch, M. 2002. Fibronectin mediates Opc dependent internalization of Neisseria meningitidis by human brain microvascular endothelial cells. Mol. Microbiol., 46: 933-946.
  21. Kurz, S., Hübner, C., Aepinus, C., Theiss, S., Guckenberger, M., Panzner, U., Weber, J., Frosch, M. , Dietrich, G., 2003. Transcriptome-based antigen identification for Neisseria meningitidis . Vaccine, 21: 768-775.
  22. Suerbaum, S. Josenhans, C., Sterzenbach, T., Drescher, B., Brandt, P., Bell, M., Dröge, M., Fartmann, B., Fischer, H.-P., Ge, Z., Hörster, A., Holland, R., Klein, K., König, J., Macko, L., Mendz, G.L., Nyakatura, G., Schauer, D.B., Shen, Z., Weber, J., Frosch, M., Fox, J.G. 2003. The complete genome sequence of the carcinogenic bacterium Helicobacter hepaticus . Proc. Natl. Acad. Sci. USA., 100: 7901-7906.
  23. Claus, H., Borrow, R., Achtman, M., Morelli, G., Kantelberg, C., Longworth, E., Frosch, M. , Vogel, U. 2004. Genetics of capsule O-acetylation in serogroup C, W-135 and Y meningococci. Mol. Microbiol. 51: 227-239.
 

 

 

 
   
   
   
     
Optimized for Internet Explorer version 5.0 or higher
Last update on 30.03.2012 Webmaster
URL: https://www.pathogenomics-era.net