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You have entered the IISP: Interactive Information System on Pathogenomics

 

If you would like to insert information about your research or research group, please click to the following link to download the form. After filling it out, please send back to m.karrasch@fz-juelich.de or g.gebreselassie@fz-juelich.de.

Here you will find information about Research groups in the PathoGenoMics fields from the ERA-NET partner countries (Austria, Finland, France, Hungary, Israel, Latvia, Portugal, Slovenia and Spain).
This information is supposed to support cooperation between researchers from different European countries
and thus enhance the development of a European Research Area for PathoGenoMics .

 

The following information is available and can be searched for:

  • researcher names
  • Institution of the respective researcher, city and country of his/her institution
  • Contact data of the researcher (address, phone, email)
  • Research topics and studied microorganisms of the researcher
  • Special techniques applied by the researcher
  • Potential cooperation topics suggested by the researcher

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Name: Prof. Dr. Wehland, Jürgen
Address: Mascheroder Weg 1
Institution: GBF
 
City: Braunschweig Zip: D-38124
Country: Germany Phone: +49-531/6181-415
    Fax: +49-531/6181-444
Email:
www:

 

Research Topics:
The Department of Cell Biology is focussing on the interactions, i.e. the crosstalk between host cells and bacterial pathogens, which include a) the invasion mechanisms of various pathogens, b) the signal processes within the host cell that are induced and/or modified by these pathogens and c) the actin cytoskeleton as the central target structure of bacterial pathogens. As a consequence, understanding the molecular basis of actin dynamics is of prime interest. Functional genomics of bacterial pathogenicity requires the analysis of gene expression at the protein level and the study of protein-protein interactions as a complement to sequencing and transcription analyses. Parallel to the ongoing manual annotation of the L. welshimeri and L. seeligeri genomes we focus on the comparative analysis of the surface subproteomes, i.e., secretory, cell wall-associated and membrane proteins, of L. monocytogenes aiming at the generation of reference proteome profiles and the identification of further virulence-related proteins involved in host-pathogen interactions. The latter topic is mainly based on the analysis of isogenic deletion mutants and comparisons with apathogenic Listeria species. We developed new procedures for the isolation and analysis of defined surface subproteomes based on electrophoretic and chromatographic protein or peptide separations in combination with mass spectrometry, and several bioinformatic tools such as, e.g.""LaneSpector"", a visualization tool for the systematic comparison of theoretical and experimental data and data validation, and MineBlast, a tool that that supports the process of systematic re- and new-annotation of gene functions based on the visualization of comprehensive literature search results. Further work will focus on the signal exchange between the pathogen and eukaryotic host cells in our established model system.

 

Organisms studied:
  • Escherichia coli
  • Listeria monocytogenes
  • Pseudomonas aeruginosa
  • Salmonellae
  • Shigella flexneri

 

Special methods / technologies:
2D-PAGE, MLADI-TOF, nLC-MS/MS, DNA-Arrays, video microscopy, mouse facilty, GMP facility

 

Suggestions for potential research cooperations:
 
   
   
   
     
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