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You have entered the IISP: Interactive Information System on Pathogenomics

 

If you would like to insert information about your research or research group, please click to the following link to download the form. After filling it out, please send back to m.karrasch@fz-juelich.de or g.gebreselassie@fz-juelich.de.

Here you will find information about Research groups in the PathoGenoMics fields from the ERA-NET partner countries (Austria, Finland, France, Hungary, Israel, Latvia, Portugal, Slovenia and Spain).
This information is supposed to support cooperation between researchers from different European countries
and thus enhance the development of a European Research Area for PathoGenoMics .

 

The following information is available and can be searched for:

  • researcher names
  • Institution of the respective researcher, city and country of his/her institution
  • Contact data of the researcher (address, phone, email)
  • Research topics and studied microorganisms of the researcher
  • Special techniques applied by the researcher
  • Potential cooperation topics suggested by the researcher

If you have any comments/questions or if you would like to add some information, please contact m.karrasch@fz-juelich.de

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Name: Prof. Dr. Pócsi, István
Address:
Institution: University of Debrecen, Fac. Sci. Dept. Microbiol.
 
City: Zip:
Country: Hungary Phone:
    Fax:
Email: pocsi@tigris.unideb.hu
www:

 

Research Topics:
We are studying the elements of general and specific oxidative stress responses in the filamentous model fungus Aspergillus nidulans using EST-based DNA microarrays. Our strategic aim is to transfer functional information gained in this model system to the opportunistic human pathogen Aspergillus fumigatus. Major regulatory elements are identified and analysed parallel in both microorganisms. We are also interested in mechanism of action studies on small molecular weight antifungal proteins of fungal origin. We are planning to compare global gene expression patterns recorded in antifungal protein treated and untreated control wild-type as well as in antifungal protein resistant mutant Aspergillus nidulans strains to identify possible molecular targets. We are also investigating the mechanism of fungal cell death and ageing processes. We would like to support the hypothesis that fungal cell death (apoptosis), hyphal fragmentation, autolysis are intimately coupled but differentially regulated processes in submerged Aspergillus and Penicillium cultures. All the projects presented here clearly aim at the development of new type antifungal agents. Obviously, a deeper understanding of fungal oxidative defense, cell death and autolysis would hopefully give us the tool to keep these important physiological processes under tight control.

 

Organisms studied:
  • Aspergillus fumigatus
  • Aspergillus nidulans
  • Aspergillus spp.
  • Candida spp.
  • Penicillium spp.

 

Special methods / technologies:
DNA microarrays, RT-PCR, Northern blot, confocal microscope, EM

 

Suggestions for potential research cooperations:
My opinion is that an EC-level collaboration between labs working on human pathogenic fungi, either as
an independent programme or as a well-defined part of a wider Pathogenomics programme package, were
highly beneficial and effective.
 
   
   
   
     
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