You have entered the IISP: Interactive Information System on Pathogenomics
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Here you will find information about Research groups in the PathoGenoMics fields from the ERA-NET partner countries (Austria, Finland, France, Hungary, Israel, Latvia, Portugal, Slovenia and Spain).
This information is supposed to support cooperation between researchers from different European countries
and thus enhance the development of a European Research Area for PathoGenoMics .
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- researcher names
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- Research topics and studied microorganisms of the researcher
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|Name:||Prof. Dr. Martinez Garcia, Jose Pedro|
|Address:||Avda. Vicente Andres Estelles S/N. Burjassot|
|Institution:||Facultad de Farmacia, Universidad de Valencia|
|Virulence factors, mechanisms of pathogenicity, host-parasite relationships, biofilms, hydrophobins, proteomics We are currently working on the characterization of protein components present in the matrix of extracellular polymeric material (MEPM) of biofilms generated by the opportunistic fungal pathogen Candida albicans using an experimental approach based in a proteomic analysis. The scientific goals pursued in this project are: i) To characterize the MEPM proteome (subproteome) of C. albicans biofilms in order to investigate whether there are biofilm-specific protein species or that are preferentially expressed in this structure. These protein species may be potential targets for new agents for the treatment and/or prevention of C. albicans infections. ii) To investigate the role of these MEPM protein components in the formation and maintenance of the tridimensional biofilm structure. iii) To study the biofilm structure and the interaction of protein species with the remaining MEPM components, mostly polysaccharides, by means of laser scanning confocal microscopy (LSCM) using double tagging with GFP for the protein moieties and polysaccharide-specific dye reagents. This experimental approach would also allow the study of biofilms formed by C. albicans in association with some bacterial species such as Pseudomonas aeruginosa y Staphylococcus aureus. iv) To compare the MEMP proteome of biofilms formed by a C. albicans collection strain (see previous sections) with the MEMP proteome of biofilms formed by clinical strains of this fungus isolated from blood samples of patients harbouring indwelling devices (stents, shunts, implants, catheters, endotracheal tubes, p) made of biocompatible materials and to correlate data from the proteomic analysis with those from the antifungal sensibility testing perfomed on fungal cells present in biofilms.|
|Special methods / technologies:|
|Proteomics, electrophoresis, chromatography, immunological procedures (Western blotting, immnufluorescence, scanning laser confocal microscopy.|
|Suggestions for potential research cooperations:|