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Here you will find information about Research groups in the PathoGenoMics fields from the ERA-NET partner countries (Austria, Finland, France, Hungary, Israel, Latvia, Portugal, Slovenia and Spain).
This information is supposed to support cooperation between researchers from different European countries
and thus enhance the development of a European Research Area for PathoGenoMics .

 

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  • Institution of the respective researcher, city and country of his/her institution
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Name: Prof. Dr. Gonzales de la Campa, Adela
Address: Ctra.Majadahonda a Pozuelo, km. 2,2
Institution: Centro national de Microbiologia, Instituto de Salud Carlos III
 
City: Madrid Zip: ES-28220
Country: Spain Phone:
    Fax:
Email: agcampa@isciii.es
www:

 

Research Topics:
Molecular bases of antimicrobial susceptibility of Streptococcus pneumoniae and viridans group streptococci (VS): 1. Amino alcohol antimalarial drugs, such as optochin, quinine, mefloquine. The optochin susceptibility test is routinely used in the clinical laboratories for the differentiation of S. pneumoniae and VS. Amino alcohol antimalarial drugs target the c and a subunits of the F0 complex of the F0F1 H+-ATPase [1-4]. S. pneumoniae could be used as a model system to test the activity of new antimalarial drugs, and, on the other hand, given that the F0F1-ATPase is essential for cell viability [5], it is also an appropriate target for the development of new antimicrobial drugs [3]. The F0F1-ATPase creates a transmembranal proton gradient and control the intracellular pH, its expression being regulated at the level of initiation of transcription [6]. 2. Fluoroquinolones (Fq). We have characterized the pneumococcal genes encoding the intracellular targets of Fq: DNA topoisomerase IV and DNA gyrase enzymes [7-9], and demonstrated at the genetic [7] and biochemical level [10] that DNA topoisomerase IV is a primary target for most Fqs, being DNA gyrase a secondary target. SV share the same mechanism of Fq resistance [11] and are acting as a reservoir of Fq resistance. We have described the emergence of Fq resistance in S. pneumoniae [12] [13] and detected several Fq-resistant isolates carrying recombinant DNA topoisomerase genes [14]. A different gene organization of the DNA topoisomerase IV genes in these recombinant strains and in VS (parE-.ant-parC) when compared with non-recombinant S. pneumoniae isolates (parE-parC) is an evidence that VS are acting as DNA donors [15]. Recent investigations have shown that Fq-resistant S. pneumoniae are being selected among isolates of the major epidemic multi-resistant clones, including recombinant strains [13]. On the other hand, our group has described the presence of Fq efflux pumps in S. pneumoniae [13] and in VS [16].

 

Organisms studied:
  • streptococci (Viridans group)
  • Streptococcus pneumoniae

 

Special methods / technologies:

 

Suggestions for potential research cooperations:
Characterization of \\\"atypical\\\" S. pneumoniae strains
Clonal structure of fluoroquinolone-resistant S. pneumoniae strains
Genomic studies on the acid tolerance response of S. pneumoniae
 
   
   
   
     
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