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Here you will find information about Research groups in the PathoGenoMics fields from the ERA-NET partner countries (Austria, Finland, France, Hungary, Israel, Latvia, Portugal, Slovenia and Spain).
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Name: Prof. Dr. Mendez Alvarez, Sebastian
Address: Ctra. Del Rosario, S/N
Institution: Hospital Universit. Nuestra Senora de Candelaria, Gobierno Canarias
 
City: Santa Cruz de Tenerife Zip: ES-38010
Country: Spain Phone:
    Fax:
Email:
www:

 

Research Topics:
The methicillin-resistant Staphylococcus aureus (MRSA) population in the Hospital Universitario Nuestra Seņora de Candelaria over a 5-year period (1998 to 2002) was marked by shifts in the circulation of pandemic clones. Here, we investigated the emergence of high-level mupirocin resistance (Hi-Mupr). In addition to clonal spread, transfer of ileS2-carrying plasmids played a significant role in the dissemination of Hi-Mupr among pandemic MRSA lineages. Most hospital-acquired methicillin-resistant Staphylococcus aureus (MRSA) isolates are members of five MRSA pandemic lineages or clonal complexes (CCs), namely, CC5, CC8, CC22, CC30, and CC45. Mupirocin constitutes the cornerstone of avoidance of MRSA carriage and ulterior infection, but resistance has emerged, and its spreading is worrisome, with transferable high-level mupirocin resistance (Hi-Mupr) being of clinical significance. Hi-Mupr is associated with an additional isoleucyl-tRNA synthetase that is encoded by the ileS2 gene. The ileS2 gene was commonly reported on plasmids that differed in size, restriction patterns, and ability to be transferred in conjugation experiments. We reported that 95.5% of the 375 MRSA isolates obtained from patients at Hospital Universitario Nuestra Seņora de Candelaria (located in Tenerife, Canary Islands, Spain) between 1998 and 2002 belonged to six clones fitting in pandemic lineages (i.e., CC5, CC8, CC22, and CC30) (20). Now, we are investigating Hi-Mupr in such a staphylococcal population. All major MRSA pandemic clones already circulating in the hospital acquired ileS2-carrying plasmids, resulting in a multiclonal population structure. In addition to clonal spread and plasmid transfer, the finding of the ileS2 gene in plasmids differing in size and restriction patterns show that gene transposition constitutes an important mode of dissemination of Hi-Mupr. Intervention strategies in the current scenario should identify dissemination of MRSA clones and/or ileS2-carrying mobile elements as well as genomic differences between diferent clones and clonal complexes.

 

Organisms studied:
  • Campylobacter spp.
  • Candida spp.
  • Enterococci
  • Staphylococcus

 

Special methods / technologies:
Sequencing Pulsed Field Electrophoresis Genomic Subtraction

 

Suggestions for potential research cooperations:
 
   
   
   
     
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