You have entered the IISP: Interactive Information System on Pathogenomics
If you would like to insert information about your research or research group, please click to the following link to download the form. After filling it out, please send back to firstname.lastname@example.org or email@example.com.
Here you will find information about Research groups in the PathoGenoMics fields from the ERA-NET partner countries (Austria, Finland, France, Hungary, Israel, Latvia, Portugal, Slovenia and Spain).
This information is supposed to support cooperation between researchers from different European countries
and thus enhance the development of a European Research Area for PathoGenoMics .
The following information is available and can be searched for:
- researcher names
- Institution of the respective researcher, city and country of his/her institution
- Contact data of the researcher (address, phone, email)
- Research topics and studied microorganisms of the researcher
- Special techniques applied by the researcher
- Potential cooperation topics suggested by the researcher
If you have any comments/questions or if you would like to add some information, please contact firstname.lastname@example.org
|Name:||Dr. Gaudu, Philippe|
|Country:||France||Phone:||01 34 65 20 80|
|Our team studies how two bacterial strains of the same genus, a food strain ( Lactococcus lactis ) and a pathogen ( Streptococcus agalactiae ), adapt to their environment with respect to their redox systems. As they share at least 50% of their gene pool, it is likely that they have numerous similar properties. Our team recently found that both these bacteria shift from a fermentation to a respiratory metabolism if cofactors, required to complete the respiratory chain, are present in an aerated environment. L. lactis and S. agalactiae are indeed auxotrophs for heme, and heme and quinone, respectively. Compared to fermentation, respiration allows a more efficient use of the carbon source and a very good conservation of cells in stationary phase in vitro. We are now focused on the characterization of respiration metabolism at the molecular level (genetics and proteomics), and trying to better define its role in the colonization of natural niches of these two species. The role of respiration in S. agalactiae virulence is being studied in a murine model.|
|Special methods / technologies:|
|Two-Dimensional gels, mutagenesis.|
|Suggestions for potential research cooperations:|