You have entered the IISP: Interactive Information System on Pathogenomics
If you would like to insert information about your research or research group, please click to the following link to download the form. After filling it out, please send back to firstname.lastname@example.org or email@example.com.
Here you will find information about Research groups in the PathoGenoMics fields from the ERA-NET partner countries (Austria, Finland, France, Hungary, Israel, Latvia, Portugal, Slovenia and Spain).
This information is supposed to support cooperation between researchers from different European countries
and thus enhance the development of a European Research Area for PathoGenoMics .
The following information is available and can be searched for:
- researcher names
- Institution of the respective researcher, city and country of his/her institution
- Contact data of the researcher (address, phone, email)
- Research topics and studied microorganisms of the researcher
- Special techniques applied by the researcher
- Potential cooperation topics suggested by the researcher
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|Address:||Genetics of Biofilms Laboratory URA CNRS 2172 Department of Microbiology INSTITUT PASTEUR 25 rue du Docteur Roux 75724 Paris CEDEX 15 FRANCE|
|Institution:||Institut Pasteur, Genetics of Biofilms Laboratory|
|Biofilms are mixed and matrix-encased communities of microorganisms that develop on surfaces in most natural and artificial environments. The studies undertaken in my laboratory basically address 2 main questions: how commensal and pathogenic Escherichia coli form biofilms? What physiological properties do these bacteria express once the biofilm is formed? We use of genetic, genomic and molecular biology approaches combined with different in vitro and in vivo biofilm models, (i) to identify bacterial factors promoting both initial surface contacts and bacterial-bacterial interactions during the tri-dimensional development of the biofilm (pili, surface adhesins and extracellular polysaccharide); (ii) to investigate biofilm-specific properties or metabolism with particular emphasis on competitive bacterial interactions within mixed biofilms (bacterial interference molecule in mixed biofilms contexts); and iii) to study the early stage of bacterial contact with surfaces in collaborations with biophysicists and surface-chemists (study of very early stages of bacteria adhesion, influence of surface nature on genetic responses). These approaches contribute to a better fundamental understanding of bacterial biofilm lifestyle and could reveal unsuspected biological resources that may be used by E. coli and other bacterial species to operate within bacterial communities. Moreover, some aspects of our studies are positioned at the interface between fundamental and clinical/applied researches aiming at developing new strategies to monitor, control or limit the extent of pathogenic or detrimental biofilms in situations in which they represent a sanitary, industrial or ecological problem.|
|Special methods / technologies:|
|Biofilm cultures in vitro (microfermentors, flow cells) Biofilm culture in vivo (on epithelial cell) in vivo model:catheter in rat, gut colonization in mice, in zebrafish|
|Suggestions for potential research cooperations:|