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You have entered the IISP: Interactive Information System on Pathogenomics

 

If you would like to insert information about your research or research group, please click to the following link to download the form. After filling it out, please send back to m.karrasch@fz-juelich.de or g.gebreselassie@fz-juelich.de.

Here you will find information about Research groups in the PathoGenoMics fields from the ERA-NET partner countries (Austria, Finland, France, Hungary, Israel, Latvia, Portugal, Slovenia and Spain).
This information is supposed to support cooperation between researchers from different European countries
and thus enhance the development of a European Research Area for PathoGenoMics .

 

The following information is available and can be searched for:

  • researcher names
  • Institution of the respective researcher, city and country of his/her institution
  • Contact data of the researcher (address, phone, email)
  • Research topics and studied microorganisms of the researcher
  • Special techniques applied by the researcher
  • Potential cooperation topics suggested by the researcher

If you have any comments/questions or if you would like to add some information, please contact m.karrasch@fz-juelich.de

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Name: Prof. Dr. Serror, Pascale
Address: Domaine de Vilvert
Institution: Laboratoire de Recherches Laitières et de Génétique Appliquée
 
City: Jouy en Josas Zip: F-78350
Country: France Phone:
    Fax:
Email:
www:

 

Research Topics:
Enterococcus faecalis, colonization, pathogenicity, digestive tract Our major research interests focus on the virulence of the opportunistic pathogen Enterococcus faecalis. Enterococcus faecalis is a ubiquitous and ambivalent gram positive bacterium whose members are classified as commensal, food or clinical strains, depending on the isolate. Our research addresses two issues: The first research project consists in a comparative analysis of clinical, food and commensal isolates, by a semi-global genomic approach. Our goals: i) Genetic imprints of enterococcal factors: We are comparing genomic profiles using a DNA membrane spotted with 500 genes selected for putative opportunism factors, such as adhesins, toxins, surface proteins, secreted proteins, stress proteins, and regulators. Factors specifically associated with clinical isolates will be earmarked. ii) Comparison of expression levels of genes associated with opportunism in clinical and food isolates, grown in different experimental conditions. In particular, we will examine genes present in isolates regardless of their origins (e.g., those encoding surface proteases), but that are reportedly involved in virulence. The second research project is aimed at understanding the genetic basis of E. faecalis colonisation and pathogenicity, using Caenorhabditis elegans and mice as models, and has two goals: i) Identify potential virulence factors by screening a targeted E. faecalis mutant library on C. elegans and then on mice. ii) Study the role of the genes in digestive tract colonisation and/or in pathogenesis. We expect that these analyses of E. faecalis virulence factors will promote a better understanding of colonisation and virulence mechanisms of this ambivalent bacterium.

 

Organisms studied:
  • Enterococcus faecalis

 

Special methods / technologies:
DNA macroarrays, Caenorhabditis elegans animal model Comparative genome hybridization Caenorhabditis elegans virulence tests

 

Suggestions for potential research cooperations:
Identification of key factors involved in reservoir colonisation and/or virulence of opportunistic pathogens has been difficult mainly because relevant animal models are lacking. Research efforts should concentrate on the development of reliable animal mo
 
   
   
   
     
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