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You have entered the IISP: Interactive Information System on Pathogenomics

 

If you would like to insert information about your research or research group, please click to the following link to download the form. After filling it out, please send back to m.karrasch@fz-juelich.de or g.gebreselassie@fz-juelich.de.

Here you will find information about Research groups in the PathoGenoMics fields from the ERA-NET partner countries (Austria, Finland, France, Hungary, Israel, Latvia, Portugal, Slovenia and Spain).
This information is supposed to support cooperation between researchers from different European countries
and thus enhance the development of a European Research Area for PathoGenoMics .

 

The following information is available and can be searched for:

  • researcher names
  • Institution of the respective researcher, city and country of his/her institution
  • Contact data of the researcher (address, phone, email)
  • Research topics and studied microorganisms of the researcher
  • Special techniques applied by the researcher
  • Potential cooperation topics suggested by the researcher

If you have any comments/questions or if you would like to add some information, please contact m.karrasch@fz-juelich.de

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Name: PD Dr. Friedrich, Alexander W.
Address: Robert Koch Str. 41
Institution: Institute of Hygiene, University Hospital Münster
 
City: Münster Zip: DE-48151
Country: Germany Phone: 0049-251-8355366
    Fax: 0049-251-8355366
Email:
www:

 

Research Topics:

Shiga toxin-producing Escherichia coli (STEC) and especially enterohaemorrhagic E. coli (EHEC) cause a variety of diseases ranging from diarrhoea to hemorrhagic colitis and hemolytic uremic syndrome (HUS). EHEC associated HUS is nowadays the most common cause of acute renal failure in children. Pathogenesis of EHEC-mediated diseases are not completely understood. During last years our group has identified several potential EHEC virulence factors including adhesins, such as Sfp fimbriae and EHEC factor for adherence (Efa-1), and toxins, such as cytolethal distending toxin (CDT), an RTX toxin and a vacuolating toxin.

During the project, genome and transcriptome analysis of new virulence determinants of STEC and the compared genomic analysis of clones and their putative virulence factors with high clinical priority, such as Sorbitol-fermenting (SF) EHEC O157:HNM is performed. Furthermore, Shiga toxin subtyping and its implication in the risk analysis of severe diseases is performed focussing on the phylogenetic analysis of STEC and EHEC. Since there is presently no therapy for EHEC infections, results of these experiments are expected to enable developing new strategies to prevent and treat human diseases caused by EHEC.

 

Organisms studied:
  • Enterohaemorrhagic Escherichia coli O157:H7
  • Escherichia coli
  • Shiga Toxin-producing Escherichia coli (STEC) non-O157
  • Sorbitol-fermenting Escherichia coli O157:HNM

 

Special methods / technologies:
  • High-troughput sequencing technology
  • PCR conventional and quantitative RT-PCR
  • Southern blot, microarrays
  • Sequence analysis
  • New bioinformatic tools for the high quality analysis of sequencing data

 

Suggestions for potential research cooperations:
 
   
   
   
     
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