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If you would like to insert information about your research or research group, please click to the following link to download the form. After filling it out, please send back to m.karrasch@fz-juelich.de or g.gebreselassie@fz-juelich.de.

Here you will find information about Research groups in the PathoGenoMics fields from the ERA-NET partner countries (Austria, Finland, France, Hungary, Israel, Latvia, Portugal, Slovenia and Spain).
This information is supposed to support cooperation between researchers from different European countries
and thus enhance the development of a European Research Area for PathoGenoMics .

 

The following information is available and can be searched for:

  • researcher names
  • Institution of the respective researcher, city and country of his/her institution
  • Contact data of the researcher (address, phone, email)
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Name: Full Professor Sá-Correia, Isabel
Address: IBB-Institute for Biotechnology and Bioengineering Centre for Biological and Chemical Engineering, Chemical and Biological Engineering Department Av. Rovisco Pais 1049-001 Lisboa, Portugal
Institution: IBB-Institute for Biotechnology and Bioengineering
 
City: Lisboa Zip: 1049-001
Country: Portugal Phone: +351.218417682
    Fax: +351.218417233
Email: isacorreia@ist.utl.pt
www: http://dequim.ist.utl.pt/cebq/bsrg/Team/iscorreia.html

 

Research Topics:

PATHOGENOMICS- Pathogenomic studies are focused on the adaptive strategies employed by bacteria of the Burkholderia cepacia complex to adapt to the cystic fibrosis lung stressing environment, in particular to aggressive antimicrobial therapy, and to be involved either in chronic infection or in acute infection which may lead to death with the cepacia syndrome. Microarray analysis (in the context of the Burkholderia array project funded by the Cystic Fibrosis Foundation/Therapeutics Inc), expression proteomics and comparative genome analysis are the main technologies explored. The epidemiological survey of Bcc-mediated-respiratory infections in CF patients receiving care at the main Portuguese CF Centre in Lisbon has been carried out during the last 10 years.

TOXICOGENOMICS- Toxicogenomic studies aim at predicting toxic side effects of drugs/industrial and environmental chemicals on human health earlier in time and at lower dosages in order to provide a clearer picture of the mechanism of toxicity than traditional toxicology methods.Toxicogenomic technologies are powerful tools for mechanistic and predictive toxicology and health risk assessment. They may also be applied in the drug research and to optimize the drug development process. As model organism, we have been exploring the yeast Saccharomyces cerevisiae whose signalling pathways and molecular components are conserved among eukaryotic organisms. We obtained mechanistic insights into the toxicity of, and resistance to, herbicides and agricultural fungicides and identified new drug targets and resistance mechanisms to anticancer and antimalarial drugs. Bioinformatics tools, including chemometrics, are implemented and used to integrate the data coming from genome-wide technologies envisaging a systems biology approach to Toxicogenomics problems The YEASTRACT database (www.yeastract.com) was prepared and is being updated and consolidated

1- Teixeira M. C., Duque P., Sá-Correia I., “Environmental Genomics: mechanistic insights into toxicity and resistance to the herbicide 2,4-D”, Trends in Biotechnology, 25: 363-370, 2007.

2-Santos P.M., Simões T., Sá-Correia I., "Insights into yeast adaptive response to the agricultural fungicide mancozeb: a toxicoproteomics approach", PROTEOMICS, 19, 657-670, 2009

3-dos Santos, S.C., Sá-Correia I., Genome-wide identification of genes required for yeast growth under imatinib stress: vacuolar H+-ATPase function is an important target of this anticancer drug, OMICS: A Journal of Integrative Biology DOI: 10.1089/omi.2008.0086

4-Teixeira, M. C., Monteiro, P., Jain, P., Tenreiro, S., Fernandes, A. R., Mira, N. P., Alenquer, M., Freitas, A. T., Oliveira, A. L., Sá-Correia, I., “The YEASTRACT database: a tool for the analysis of transcriptional regulatory associations in Saccharomyces cerevisiae”, Nucleic Acids Research, Database Issue, 34: D446-D451, 2006

EFFLUX PUMPS and MULTIDRUG RESISTANCE- Research focuses the functional analysis and expression regulation of the poorly characterized yeast multidrug resistance (MDR) transporters of the major facilitator superfamily and application of the knowledge obtained to guide the analysis of their homologous uncharacterized drug-H+ antiporters in higher eukaryotes 5-Sá-Correia I., dos Santos S.C., Teixeira M.C., Cabrito T.R., Mira N.P., Drug:H+ antiporters in chemical stress response in yeast. Trends in Microbiology, 17, 22-31, 2009

 

Organisms studied:
  • Burkholderia cepacia
  • Pseudomonas putida
  • Saccharomyces cerevisiae

 

Special methods / technologies:
Expression proteomics (or quantitative proteomics) Chemical genomics, NMR-based metabolomics Genome-wide expression data analysis using the Yeastract database (http://www.yeastract.com/) and other bioinformatics tools

 

Suggestions for potential research cooperations:
 
   
   
   
     
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