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If you would like to insert information about your research or research group, please click to the following link to download the form. After filling it out, please send back to m.karrasch@fz-juelich.de or g.gebreselassie@fz-juelich.de.

Here you will find information about Research groups in the PathoGenoMics fields from the ERA-NET partner countries (Austria, Finland, France, Hungary, Israel, Latvia, Portugal, Slovenia and Spain).
This information is supposed to support cooperation between researchers from different European countries
and thus enhance the development of a European Research Area for PathoGenoMics .

 

The following information is available and can be searched for:

  • researcher names
  • Institution of the respective researcher, city and country of his/her institution
  • Contact data of the researcher (address, phone, email)
  • Research topics and studied microorganisms of the researcher
  • Special techniques applied by the researcher
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Name: Prof. Dr. Süssmuth, Roderich
Address: Technische Universität Berlin Institut für Chemie / FG Organische Chemie Strasse des 17. Juni 124 / Sekr. TC2 D-10623 Berlin
Institution: Institut für Chemie / FG Organische Chemie
 
City: Berlin Zip: D-10623
Country: Germany Phone: 49-(0)30-314-24205
    Fax: 49-(0)30-314-79651
Email: suessmuth@chem.tu-berlin.de
www: http://www2.tu-berlin.de/fb5/Suessmuth/index.html

 

Research Topics:
  1. Investigation and structure elucidation of bacterial and fungal pathogenicity factors
    In previous work our group has discovered salmochelin (Bister et al. 2004) a siderophor acting as a pathogenicity factor synthesized by E. coli and Salmonella species. Salmochelin is an enterobactin-like siderophor and secures iron-transport under iron-low conditions. We are continuing to investigate small molecule pathogenicity factors synthesized by bacteria and fungi in interaction with plants or mammals as host systems. We are further interested in the discovery and structure elucidation of small molecule pathogenicity factors from various bacterial or fungal species.
  2. Chemical and biological screening and genome mining for new antibiotics, combinatorial biosynthesis
    Our group is interested in the screening and structure elucidation of novel antibiotics from fungi and bacteria. the particular expertise is in elucidation of the structure of a variety of natural products such as polyketides, peptides, glycopeptides, lipids and natural products of mixed biosynthetic origin. Most recently, the structurally complex last-resort vancomycin-type antibiotics (Bischoff et al., 2001a, 2001b and 2005, Weist et al., 2002 and 2004), fresh-water peptide toxins, the abyssomicins (Bister et al., 2004), the fluostatins (Baur et al., 2006 and Schneider et al., 2006) and the proximicins (Schneider et al., 2008; Fiedler et al., 2008) were characterized. Abyssomycins are polyketide antibiotics from the deep-sea actinomycete Verrucosispora, and were isolated from a directed assay in the p-aminobenzoic acid/tetrahydrofolate biosynthesis pathway (Riedlinger et al., 2004). Structures of abyssomicins B, C and D were determined by ESI-FTICR-MS, 2D-NMR and X-ray analysis. The absolute configuration was determined by chemical derivatization with chiral reagents (Mosher/Helmchen) and subsequent NMR-analysis. With 4-5 ring systems, the abyssomicins are highly complex polyketide antibiotics (MW ~ 350) and focus a novel antibiotic target (p-amino benzoic acid biosynthesis). In several review articles, the abyssomicins were selected as one of the most interesting natural products in the past 5 years (Hill et al., 2004; Clardy et al., 2006) and are already the target of several total synthetic attempts (Nicolaou and Harrison, 2006). The same is true for other antibiotics e.g. fluostatins (Danishefski et al.2008) and arylomycins (Romesberg et al. 2007) One recent focus of the research is the involvement in the genome project and secondary metabolite investigation of Bacillus amyloliquefaciens (Chen et al. 2007). For B. amyloliquefaciens, three polyketides have been identified and assigned to the corresponding gene cluster (Chen et al. 2006; Schneider et al. 2007; Chen et al. 2007). These results have implications for the antibiotic production of all Bacillus species.

 

Organisms studied:
  • Actinomycetes
  • Bacillus subtilis
  • Beauveria bassiana
  • E. coli
  • Fusarium oxysporum
  • Salmonellae

 

Special methods / technologies:
  • Structure elucidation of secondary metabolites, protein overexpression, enzyme kinetics, enzyme inhibition, antibiotics, natural product screening, peptide synthesis, organic synthesis, bioanalytics.
  • HPLC-ESI-MS, 2D NMR spectroscopy, GC-MS, amino acid analysis.

 

Suggestions for potential research cooperations:
 
   
   
   
     
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