You have entered the IISP: Interactive Information System on Pathogenomics
If you would like to insert information about your research or research group, please click to the following link to download the form. After filling it out, please send back to firstname.lastname@example.org or email@example.com.
Here you will find information about Research groups in the PathoGenoMics fields from the ERA-NET partner countries (Austria, Finland, France, Hungary, Israel, Latvia, Portugal, Slovenia and Spain).
This information is supposed to support cooperation between researchers from different European countries
and thus enhance the development of a European Research Area for PathoGenoMics .
The following information is available and can be searched for:
- researcher names
- Institution of the respective researcher, city and country of his/her institution
- Contact data of the researcher (address, phone, email)
- Research topics and studied microorganisms of the researcher
- Special techniques applied by the researcher
- Potential cooperation topics suggested by the researcher
If you have any comments/questions or if you would like to add some information, please contact firstname.lastname@example.org
|Name:||Dr. Levesque, Roger C.|
|Address:||Institut de biologie intégrative et des systèmes (IBIS), Charles-Eugène Marchand Bld., Université Laval, Québec, Canada. G1V 0A6.|
|Institution:||Institut de biologie intégrative et des systèmes (IBIS)|
|In vivo functional genomics of Pseudomonas aeruginosa and screening of signature-tagged mutagenesis mutants in animals models of chronic lung infection. Integrative and systems biology in host-pathogen The vast knowledge accumulating from several completed Pseudomonas genome sequences and other pseudomonads including P. putida and P. fluorescens has increased the interest of not only in essential genes in bacterial pathogenesis but more so in approaches of integrative biology. In addition to the development of new technologies for high throughput analysis in vivo such as STM, transcriptome profiling, metabolomics and in vivo competitive index, the analysis of P. aeruginosa gene function progresses towards the study of interactions between the components of this biological system, and how these interactions give rise to survive in variosu ecological niches. From the current proposal, genes characterized as essential in bacterial pathogenesis represent potential targets for development of new antibacterial treatments including vaccines. Functional genomics analysis should rapidly identify promising antibacterial targets for the synthesis of new generation of antibiotics and inhibitors. Recently, we have used the promising approach of genomics and essential genes coupled to the mix-and-split combinatorial chemistry approach and phage display to develop a combinatorial enzymatic assay for the screening of new bacterial cell wall inhibitors and peptides. We now have antimicorbial peptides having in vivo activity in the nanomolar range.|
|Special methods / technologies:|
|The IBIS has 3 major platforms including:1) Histology, cell and molecular imaging; 2) bio-informatics; 3) nucleic acids analysis using a Roche FLX 454 for complete bacterial genome sequencing and assembly. RNA-Seq deep sequencing, transcriptomics profiling, QPCR, genome assembly, comparisons and annotation|
|Suggestions for potential research cooperations:|
|Complete bacterial genome sequencing and assembly of any bacterial species in the network ERA-Net
Signature-tagged mutagenesis libraries and development of in vivo cell or animal assays for STM screening.
Comparative genomics and bio-informatics annotation