You have entered the IISP: Interactive Information System on Pathogenomics
If you would like to insert information about your research or research group, please click to the following link to download the form. After filling it out, please send back to email@example.com or firstname.lastname@example.org.
Here you will find information about Research groups in the PathoGenoMics fields from the ERA-NET partner countries (Austria, Finland, France, Hungary, Israel, Latvia, Portugal, Slovenia and Spain).
This information is supposed to support cooperation between researchers from different European countries
and thus enhance the development of a European Research Area for PathoGenoMics .
The following information is available and can be searched for:
- researcher names
- Institution of the respective researcher, city and country of his/her institution
- Contact data of the researcher (address, phone, email)
- Research topics and studied microorganisms of the researcher
- Special techniques applied by the researcher
- Potential cooperation topics suggested by the researcher
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|Name:||Dr. Herskovits, Anat A.|
|Address:||Department of Molecular Microbiology and Biotechnology Tel-Aviv University, Tel Aviv, 69978, Israel|
|Institution:||Department of Molecular Microbiology and Biotechnology|
|Country:||Israel||Phone:||(972)-3-640-7502 lab: 7505|
|Our lab is focused on understanding the interactions between bacterial pathogens and the mammalian innate immune system. Innate immune cells, such as macrophages, express receptors that recognize conserved molecules of microbial origin, leading to host immune responses. Using specific recognition of microbial ligands, macrophages can discriminate between viruses and bacteria, extracellular and intracellular microorganisms and live or dead microorganism. The information integrated from the different immune receptors is crucial for the development of proper innate and acquired immune responses. Ironically, while macrophages are important effector cells of the immune system they are permissive hosts for intracellular pathogens, such as Listeria monocytogenes, and how pathogenic bacteria activate and/or manipulate host immune responses is central to the understanding of host-pathogen interactions. In our lab we are focusing on the intracellular bacterial pathogen, L. monocytogenes. L. monocytogenes enters host cells through passive uptake by phagocytosis or by active invasion of non-phagocytic cells. Upon entry into the host cytosol, L. monocytogenes activates a host transcriptional response that can be monitored by the robust expression and synthesis of the cytokine Interferon-b (IFN-b) leading to a Type I interferon response. In attempt to find L. monocytogenes genes that are involved in activation of Interferon-b response in macrophages, we performed an unbiased genetic screen of a L. monocytogenes transposon library for mutants that induced an enhanced or diminished Interferon-b response upon infection of macrophages. Interestingly, in this screen we found 3 independent bacterial multi-drug resistance (MDR) transporter systems, from the major facilitator super family that controlled the magnitude of the Interferon-b response. Bacterial MDRs are associated with resistance to antibiotics and other toxic compounds. We are interested in studying the mechanism by which these bacterial MDR transporters (and other bacterial mechanisms) modulate innate immune responses.|
|Special methods / technologies:|
|Gene expression analysis, signaling pathways live cell reporters, bacterial genetic screens|
|Suggestions for potential research cooperations:|
|studying innate immune responses to bacterial pathogens
studying MDR transporters in bacterial pathogenes