You have entered the IISP: Interactive Information System on Pathogenomics
If you would like to insert information about your research or research group, please click to the following link to download the form. After filling it out, please send back to email@example.com or firstname.lastname@example.org.
Here you will find information about Research groups in the PathoGenoMics fields from the ERA-NET partner countries (Austria, Finland, France, Hungary, Israel, Latvia, Portugal, Slovenia and Spain).
This information is supposed to support cooperation between researchers from different European countries
and thus enhance the development of a European Research Area for PathoGenoMics .
The following information is available and can be searched for:
- researcher names
- Institution of the respective researcher, city and country of his/her institution
- Contact data of the researcher (address, phone, email)
- Research topics and studied microorganisms of the researcher
- Special techniques applied by the researcher
- Potential cooperation topics suggested by the researcher
If you have any comments/questions or if you would like to add some information, please contact email@example.com
|One of our main interest focuses on the role of iron in host pathogen interaction. We focus on how iron affects cell mediate immune effector pathways of macrophages, and the course of infections with our defined pathogens. We also investigate the pathways by which cells of the innate immune system modulate iron homeostasis upon pathogen entry and to which extent this leads to growth arrest of pathogens. To study the role of pathogen siderophore systems (enterobactin, Salmochelin in case of Salmonella and ferricrocin in Aspergillus fumigatus) we use such siderophore deficient mutants which are made available through our collaborators to study the impact of these siderophore systems on innate immune function of macrophages, cellular iron homeostasis, pathogenicity of these microbes and pathogen survival. Moreover, we are interested to elucidate the moed of action of NRAMP-1, a phagolysosmal protein being associated with resistance towards infections with intracellular pathogens (such as Salmonella). In terms of Pl. falciparum we study the pathogenesis of severe malarial anemia and how this relates to specific immune response patterns and parasite genes (done in collaboration with the Malaria research Institute Macha, Zambia and Howard University, Washington, DC).|
|Special methods / technologies:|
|In vitro culture system for Salmonella typhi murium, Aspergillus fumigatus and Pl. falciparum and macrophages. Mouse in vivo infection models for Salmonella Typhi murium and Aspergillus fumigatus (the latter in progress). Transient and stable transfected cell lines over expressing genes of interest. Analysis of expression of genes of interest by quantitative RT-PCR. Functional iron metabolism and transport studies in cells.|
|Suggestions for potential research cooperations:|
|In vivo model for Pl. Falciparum infection. Iron targeting strategies, Intracellaulr active iron chelaiton.|