You have entered the IISP: Interactive Information System on Pathogenomics
If you would like to insert information about your research or research group, please click to the following link to download the form. After filling it out, please send back to firstname.lastname@example.org or email@example.com.
Here you will find information about Research groups in the PathoGenoMics fields from the ERA-NET partner countries (Austria, Finland, France, Hungary, Israel, Latvia, Portugal, Slovenia and Spain).
This information is supposed to support cooperation between researchers from different European countries
and thus enhance the development of a European Research Area for PathoGenoMics .
The following information is available and can be searched for:
- researcher names
- Institution of the respective researcher, city and country of his/her institution
- Contact data of the researcher (address, phone, email)
- Research topics and studied microorganisms of the researcher
- Special techniques applied by the researcher
- Potential cooperation topics suggested by the researcher
If you have any comments/questions or if you would like to add some information, please contact firstname.lastname@example.org
|Name:||Dr. Simonet, Michel|
|Address:||1 rue du Professeur Calmette|
|Institution:||Institut Pasteur de Lille|
|Yersinia, genome, virulence genes, virulence regulation, intestinal mucosa, innate immunity, antimicrobial peptides, superantigen The general objective of our research training programme is to characterize the strategies which pathogenic bacteria use to colonize the host and to avoid the hostís defence mechanisms (both specific and non-specific). Our study model is Yersinia pseudotuberculosis, a Gram-negative bacterium responsible for digestive tract infections (ileitis and mesenteric lymphadenitis) in humans and animals. Furthermore, this micro-organism is the ancestor of Y. pestis, the causative agent for plague - a highly-contagious, life-threatening disease which still represents a public health threat, even today. Our project comprises two axes. The first focuses on the genetics of bacterial virulence and is based on the recent sequencing of the Y. pseudotuberculosis and Y. pestis genomes. It aims at i) establishing whether differential expression of the high number of genes shared by these two-related micro-organisms could explain their radically differing virulence and ii) listing the two-component-regulatory systems which control the degree of bacterial pathogenicity and identifying the corresponding regulons. These bacterial genome studies (which involve the use of DNA arrays) should reveal new virulence factors and thus potential therapeutic targets. The second research axis studies the impact of Y. pseudotuberculosis and some of its virulence factors on overall or specific gene expression in both innate and non-innate immune cells. This work is performed not only in vitro but also in vivo in conventional or genetically-modified mice. In addition to gaining a better understanding of the physiopathology of yersiniosis, the development of medical applications on the basis of this work is one of the research training programmeís anticipated outputs.|
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