You have entered the IISP: Interactive Information System on Pathogenomics
If you would like to insert information about your research or research group, please click to the following link to download the form. After filling it out, please send back to email@example.com or firstname.lastname@example.org.
Here you will find information about Research groups in the PathoGenoMics fields from the ERA-NET partner countries (Austria, Finland, France, Hungary, Israel, Latvia, Portugal, Slovenia and Spain).
This information is supposed to support cooperation between researchers from different European countries
and thus enhance the development of a European Research Area for PathoGenoMics .
The following information is available and can be searched for:
- researcher names
- Institution of the respective researcher, city and country of his/her institution
- Contact data of the researcher (address, phone, email)
- Research topics and studied microorganisms of the researcher
- Special techniques applied by the researcher
- Potential cooperation topics suggested by the researcher
If you have any comments/questions or if you would like to add some information, please contact email@example.com
|Name:||Prof. Dr. Pla Alonso, Jesus|
|Address:||Avda. Ramon y Cajal S/N|
|Institution:||Facultad de Farmacia, Universidad complutense de Madrid|
|Candida albicans virulence fungal infections MAP kinase signal transduction cell wall antifungal immune response We mainly use Candida albicans as model organism in fungal pathogenesis. This pathogenic yeast is a frequent commensal of the human intestinal and vaginal tract but under circumstances that result in an impaired host immunological response is able to colonize different target organs and generate disease. It is therefore, a paradigm of a oportunistic fungal pathogen. Our research has focused in the last years on different areas, such as the discovery of new antifungals or the study of the mechanisms of resistance to azoles. We have also developed some genetic tools. Our main line of research focuses on the role of role of signal transduction pathways mediated by MAP kinases in the virulence of this microorganism and in the biogenesis of the fungal cell wall. We have cloned some elements (HOG1, MKC1, SHO1, PBS2 etc.) in the past and we are trying to define the role of them in the pathogenesis of this fungus.|
|Special methods / technologies:|
|Normal molecular biology techniques dealing with pathogenic fungi. Mammalian cultures and in vitro and ex vivo methods to analyse host interactions|
|Suggestions for potential research cooperations:|
|Any group interested in fungal host interaction and immune response. Immunology laboratories and clinical laboratories are rather useful as complementary to our approaches.