You have entered the IISP: Interactive Information System on Pathogenomics
If you would like to insert information about your research or research group, please click to the following link to download the form. After filling it out, please send back to email@example.com or firstname.lastname@example.org.
Here you will find information about Research groups in the PathoGenoMics fields from the ERA-NET partner countries (Austria, Finland, France, Hungary, Israel, Latvia, Portugal, Slovenia and Spain).
This information is supposed to support cooperation between researchers from different European countries
and thus enhance the development of a European Research Area for PathoGenoMics .
The following information is available and can be searched for:
- researcher names
- Institution of the respective researcher, city and country of his/her institution
- Contact data of the researcher (address, phone, email)
- Research topics and studied microorganisms of the researcher
- Special techniques applied by the researcher
- Potential cooperation topics suggested by the researcher
If you have any comments/questions or if you would like to add some information, please contact email@example.com
|Name:||Dr. Gorvel, Jean-Pierre|
|Institution:||Centre d'Immunologie de Marseille-Luminy|
|Country:||France||Phone:||+33 (0)4 91 26 94 18|
|Fax:||+33 (0)4 91 26 94 30|
|Our aim is to understand how intracellular pathogenic bacteria reach their replication niche and what are the consequences on the immune system. During the past four years, we have mainly been interested in studying the host cell-bacteria interactions of Brucella and Salmonella. In Salmonella, the vacuole maturation steps have been detailed. Our research project is focused on effectors, which are important for the intracellular positioning and for the membrane dynamics of the Salmonella vacuole. We established that Brucella escapes from the endocytic pathway to interact with the endoplasmic reticulum (ER) and generate an ER-derived niche permissive for bacterial replication in macrophages. Our goal is to identify and characterize the role of bacterial molecules, which are important for the control of the vacuole maturation and for preventing immune recognition.|
|Special methods / technologies:|
|Confocal, video and 2-photon microscopy, crystallography, protein purification and interaction|
|Suggestions for potential research cooperations:|
|RNAi platform for studying the role of identified bacterial (Brucella and Salmonella) effector proteins.|